May 7, 2025 · Free PSA is measured as the proportion of free PSA to total PSA. According to older research still used as guidance right now, in men with a total PSA between 4ng/mL and 10 ng/mL: If …

Optimal Result: 25 - 50 %. Prostate-specific antigen (PSA) is a protein produced almost exclusively by prostate tissue. In the bloodstream, PSA exists in two main forms: Total PSA represents the sum of …

The total PSA range of 4.0 to 10.0 ng/mL has been described as a diagnostic "gray zone," in which the free PSA:total PSA ratio helps to determine the relative risk of prostate cancer (see table).

Jun 10, 2025 · The table below shows normal PSA levels by age and when they may be a concern. The U.S. Preventive Service Task Force as well as the American Urology Association recommends …

Jan 31, 2025 · In general, a PSA level above 4.0 ng/mL is considered abnormal and may result in a recommendation for prostate biopsy. However, because PSA levels increase with age, some doctors …

Doctors tend to categorize PSA levels in terms of “elevated” or “non-elevated,” rather than “normal” or “abnormal.” That’s because the range of what’s normal varies by age.

Dec 3, 2025 · Measuring the Free-to-Total PSA Ratio improves the accuracy of prostate cancer screening, especially when the Total PSA level falls within the “diagnostic gray zone.” This gray zone …

Jun 14, 2022 · There are no normal levels of total PSA or free PSA for men of any age. Different doctors may use different cutoff points to decide if you need a biopsy or other further testing.

In individuals with a total prostate-specific antigen (PSA) concentration between 4.0 and 10.0 ng/mL, free PSA:total PSA ratio could help determine the relative risk of prostate cancer. The lower the free …

PSA increases with age, and your PSA should be compared with normal values for men in your age group. For example, the average PSA for younger men (aged 40–49) ranges from 0.5–0.7 ng/mL, …