Tau hyperphosphorylation occurs when phosphate groups attach to tau molecules, altering and disrupting their normal functioning. Watamura, Foiani and their colleagues genetically altered mice brains ...

One of the main proteins that contributes to Alzheimer's disease is called phospho-tau (p-tau). When p-tau gets too many phosphate groups attached to it (a process called hyperphosphorylation), it ...

Researchers have found that when used on monkeys, an experimental drug slowed the process that leads the tau protein to aggregate into neuron-damaging tangles commonly seen in Alzheimer’s disease and ...

Hyperphosphorylated tau, the protein that makes up the tangles observed in tauopathies like Alzheimer’s disease, may be the consequence of an antiviral mechanism intended to protect the brain from ...

AlCl 3: Aluminium chloride; Apo-E: Apolipoprotein E; Aβ-40: amyloid β-40; Bax: Bcl-2-associated X protein; G-CSF: granulocyte-colony stimulating factor; IL-1β ...

Normally, Tau proteins stabilize microtubules and support neuronal function, but in neurodegenerative diseases such as Alzheimer's, they undergo abnormal changes that lead to aggregation and the ...

This study is led by Prof. Jian-Zhi Wang (Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology), Prof. Jie Zheng (Department of Neurobiology, School of ...

The infamous paired helical filaments (PHFs) of tau that sprawl across the brain in Alzheimer’s disease are the end products of a multiyear process. What drives tau to form these specific filaments in ...