Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger ...

A team has found a way to make the bacterial enzyme histidine kinase water-soluble, which could make it possible to rapidly screen potential antibiotics that might interfere with its functions. A ...

Proteins are among the most important molecular building blocks of life. They are chains of amino acids assembled in our cells by ribosomes, the molecular "protein factories" of our bodies. The ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

This article is based on a poster originally authored by Sunidhi Shetty, Narasimha Murthy Bandaru, Anna Moberg and Marco Manni, which was presented at ELRIG Drug Discovery 2024 in affiliation with ...