Scientists decode the 3-D structure of the calcium channel with unprecedented accuracy. With the help of electron cryo-microscopy and a new technique for detecting electrons, they were able to ...
Morning Overview on MSN
Scientists finally reveal the cause of agonizing statin side effects
Since statins first came to market in the late 1980s, muscle aches, weakness, and fatigue have driven many patients to ...
Chemists have significantly improved upon the synthesis of a molecule related to muscle and neuronal function. A research team has been busy trying to crack the puzzle of the insecticide ryanodine, a ...
Overzealous calcium signaling and dysfunctional protein degradation occur early in Alzheimer’s disease pathogenesis. Now, new evidence links the two. Two recent papers support the hypothesis that, ...
Ryanodine receptors (RyRs) are membrane proteins responsible for the release of Ca 2+ from the endoplasmic and sarcoplasmic reticulum (ER/SR) 1. Mammalian organisms contain three different isoforms ...
ARMGO Pharma Publishes Positive Phase 1b Trial Results of Rycal ® ARM210 for the Treatment of Ryanodine Receptor 1 Related Myopathies Phase 1b open label trial confirms safety and tolerability of 120 ...
Du GG, MacLennan DH . Topology and transmembrane organization of ryanodine receptors. In: Wehrens XH, Marks AR, editors. Ryanodine receptors: structure, function and ...
(A) Schematic diagram of the experimental system that detects calcium release from the endoplasmic reticulum by each ryanodine receptor. (B) Isoflurane selectively activates RyR1 (mean ± standard ...
A new recipe for making an intriguing molecule cuts the number of steps in half thanks to some clever moves and a lucky bounce. “Given that few laboratories in the world have been successful in ...
With the help of electron cryo-microscopy and a new technique for detecting electrons, they were able to elucidate the structure of the receptor with high accuracy. The animation shows how the protein ...
This news release is available in German. Whenever muscles contract, so-called ryanodine receptors come into play. Calcium ions, which are ultimately responsible for the contraction of muscle cells, ...
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