When looking at the Broncos offense, RJ Harvy could prove to be the X-factor. He had an advantageous matchup against a poor Buffalo run defense, and if he can find lanes, that'll only further help the defense with Josh Allen a mere spectator on the sideline. Projected score: Broncos 27, Bills 23 The pick: Broncos -1.5

Sunday kicks off with the Buffalo Bills on the road at AFC South champions Jacksonville Jaguars, followed by the San Francisco 49ers visiting NFC East champions Philadelphia Eagles . The New England Patriots host the Los Angeles Chargers on Sunday night.