Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

New York Giants - 12/21/2025 J.J. McCarthy Minnesota Vikings Top Plays

The Steelers took over first place in the AFC North by surviving the Ravens after an overturned touchdown in the final minutes. The Jaguars remain atop the AFC South after dismantling the Colts, who lost Daniel Jones to an Achilles injury. And the Bills all but dashed the Bengals' playoff hopes with a 39-34 win in the snow.

Week 14 in the NFL saw some phenomenal performances from players who played collegiately in the West. Each week, we highlight the region’s best pro performances from the standout alumni veterans and rookies Here are my choices for the best of them.

Bo Nix connected with Courtland Sutton on a 15-yard touchdown pass to even the Denver Broncos with the Jacksonville Jaguars.

The upsets continued into the early window of games on Sunday, with the most notable being the Panthers forcing three turnovers against NFL MVP front-runner Matthew Stafford and shocking the Rams, 31-28. The Texans also took down the Colts, further clogging up the AFC South standings with five weeks to play.

Now that the byes are all done, each NFL team has just four games remaining. Everybody has something to play for, whether they're competing for a playoff spot i

Former Oregon Ducks playing for Los Angeles franchises headlined week 16 of NFL action. Multiple Ducks continue to fight for playoff berths, while others are searching for late momentum toward the end of the regular season.