Confocal spectroscopy and total-internal-reflection fluorescence (TIRF) microscopy have emerged as powerful tools to study biological mechanisms at the single-molecule level using fluorescence ...

Researchers at Max Planck Florida Institute for Neuroscience and Stanford University teamed up to develop a new molecular tag which allowed visualization of two signaling proteins' activity in a ...

Polyprolines of different lengths, relatively stiff polypeptides, served as intramolecular “nanometer rulers” to demonstrate the highest MINFLUX resolutions in the Förster resonance energy transfer ...

Using engineered nanocomposite structures called metamaterials, a research team reports the ability to measure a significant increase in the energy transfer between molecules. This breakthrough breaks ...

A team of scientists in Florida and China have found a longer molecular ruler. They have demonstrated that an optical technique called surface energy transfer (SET) can increase the distances that ...

A team of biochemists reports a new strategy to design biosensors that report the presence of target molecules using fluorescence resonance energy transfer (FRET). It expands the capabilities of ...

FRET is based on the dipole-dipole coupling mechanism, where the energy transfer occurs through non-radiative means. It is highly efficient over short distances and sensitive to the separation between ...

Fluorescence resonance energy transfer (FRET) is a technique wherein two light-sensitive molecules transfer energy from a donor molecule to an acceptor molecule. The result is emittance of a ...

The researchers have now published their results in the journal Science ("Direct optical measuerement of intramolecular distances with angstrom precision"). What does it look like in the nanocosmos of ...

Scientist have devised a standard protocol for measuring distances in biomolecules. Architects cannot build a house without the proper dimensions of the foundation. Likewise, scientists cannot develop ...