D-cyclin proteins play a central role in cell-cycle regulation and are involved in the pathogenesis of lymphomas. In mantle-cell lymphoma, the t(11;14) translocation leads to overexpression of ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...

Cyclin-dependent kinases are a type of serine/threonine kinase which are activated by cyclins to drive the progress of the cell cycle. The cell cycle is a comprised of 4 stages, which are tightly ...

A protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA, according to new research. Cyclin D1, a protein that helps push a ...

Minimal Residual Disease Negativity Is a New End Point of Myeloma Therapy The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case ...

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Circle Pharma, a clinical-stage biopharmaceutical company dedicated to discovering and developing a new generation of macrocycle therapies, today ...

Fig 1. Putative mechanisms of resistance to CDK4/6i. Cartoon shows G1 checkpoint kinases CDK4/6 coupled to D-cyclins promoting cell cycle progression through the G1-S transition by phosphorylating Rb ...

Circle Pharma Announces Nomination of CID-165, an Oral First-in-class Cyclin D1 RxL Inhibitor, as Development Candidate for its Second Oncology Program Circle Pharma, Inc., a clinical-stage ...