BACKGROUND: The disruption of the blood–brain barrier (BBB) is a central pathogenic event in many central nervous system disorders. However, the mechanisms regulating BBB function remain incompletely ...
Increased expression of the Ang‐II (Angiotensin II) precursor AGT in aged astrocytes lead to increased Ang‐II signaling from aged astrocytes to endothelium, thus increasingblood–brain barrier (BBB) ...
Each year in the U.S., approximately 2.5 million people suffer traumatic brain injuries (TBIs). About 50,000 of these injuries will result in death, and more than 80,000 will lead to permanent ...
The phrase ‘leaky brain’ may sound like internet shorthand, but behind it lies a serious and fast-evolving area of ...
MRI scan of the human brain Flow-dependent expression of ACE2 was found to be associated with the susceptibility of brain endothelial cells to be directly infected by SARS-CoV-2. Flow-dependent ...
Empagliflozin reduced proinflammatory cytokines and oxidative stress markers in INOCA patients with CMD, improving vascular health. Treatment led to favorable shifts in endothelial extracellular ...
The endothelial glycocalyx integrates mechanical signals with vascular biology, playing a vital role in health and disease, particularly in sepsis and diabetes.
A polygenic risk score (PRS) based on genes associated with endothelial cell function identifies patients at a higher risk of coronary artery disease, according to a new study. The risk score, which ...
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