The results uncover a notable parallel between the innate and adaptive immune systems. Whereas DNA deamination targeted to endogenous immunoglobulin loci is used to trigger the diversification of ...

APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have intrinsic dinucleotide ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subjected to the host’s deamination system that includes the cytidine-to-uridine (C-to-U) deamination by apolipoprotein B messenger ...

The APOBEC family of enzymes plays an important role in the human immune system by driving changes in immune cells that aid in defense against viruses. A genetic mechanism is more likely to drive ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2004 ASCO Annual Meeting. This abstract does not include a full text component.