CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...
The evidence "for Asf1 accepting histones at the replication fork was really interesting to me, as no factor involved in chromatin disassembly at the DNA replication fork has been proposed to date to ...
Stylized DNA replication fork with nucleotides matched, 5'->3' synthesis shown, no enzymes in diagram. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to ...
AZoLifeSciences on MSN
New research reveals RFC's dynamic partnership in DNA synthesis
Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...
Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...
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