Caspase-2 is one of the most evolutionarily conserved members of the caspase family, traditionally associated with the initiation of apoptotic cell death. Recent advances have broadened its recognised ...
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...
In a major new study published in Science Advances, researchers from Adelaide University have shown that loss of the enzyme Caspase-2 drives abnormal growth in liver cells, triggering inflammation, ...
Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead increase the risk of chronic liver damage and cancer as we age. In a major new ...
Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead increase the risk of chronic liver damage and cancer as we age. Subscribe to ...
Researchers highlight that turning off this protective switch may backfire due to the increase in chronic inflammation and liver scarring. The progression of such liver condition subsequently elevates ...
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